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Papers of the Week

2021 Feb

Eur Rev Med Pharmacol Sci



Systematic literature review and Bayesian network meta-analysis of episodic cluster headache drugs.


Pompilio G, Migliore A, Integlia D
Eur Rev Med Pharmacol Sci. 2021 Feb; 25(3):1631-1640.
PMID: 33629333.


The drugs used in Europe to treat episodic cluster headache (eCH) are mainly verapamil and lithium carbonate, even though topiramate and pizotifen can be used. Galcanezumab, a humanized monoclonal antibody was approved by FDA recently for prophylaxis treatment of eCH. In order to evaluate the efficacy of galcanezumab compared to the drugs used for the preventive treatment of eCH, a systematic literature review (SLR) and network meta-analysis (NMA) of only randomized controlled trials (RCTs) was performed.