I am a
Home I AM A Search Login

Papers of the Week

2021 Feb 02

Neuroimage Clin


MR Elastography demonstrates reduced white matter shear stiffness in early-onset hydrocephalus.


Wagshul ME, McAllister JP, Limbrick DD, Yang S, Mowrey W, Goodrich JT, Meiri A, Morales DM, Kobets A, Abbott R
Neuroimage Clin. 2021 Feb 02; 30:102579.
PMID: 33631603.


Hydrocephalus that develops early in life is often accompanied by developmental delays, headaches and other neurological deficits, which may be associated with changes in brain shear stiffness. However, noninvasive approaches to measuring stiffness are limited. Magnetic Resonance Elastography (MRE) of the brain is a relatively new noninvasive imaging method that provides quantitative measures of brain tissue stiffness. Herein, we aimed to use MRE to assess brain stiffness in hydrocephalus patients compared to healthy controls, and to assess its associations with ventricular size, as well as demographic, shunt-related and clinical outcome measures.