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PLoS One



Cervical transcutaneous vagal neuromodulation in chronic pancreatitis patients with chronic pain: A randomised sham controlled clinical trial.


Muthulingam J A, Olesen S S, Hansen T M, Brock C, Drewes A M, Frøkjær J B
PLoS One. 2021; 16(2):e0247653.
PMID: 33635894.


Chronic abdominal pain is the primary symptom of chronic pancreatitis, but unfortunately it is difficult to treat. Vagal nerve stimulation studies have provided evidence of anti-nociceptive effect in several chronic pain conditions. We investigated the pain-relieving effects of transcutaneous vagal nerve stimulation in comparison to sham treatment in chronic pancreatitis patients.