Browse by Audience
Skip to content
Papers of the Week
IL-6 Signaling Mediates the Germinal Center Response, IgM Production and Nociceptive Sensitization in Male Mice after Tibia Fracture.
Abstract
Up-regulated interleukin 6 (IL-6) signaling, immune system activation, and pronociceptive autoantibodies are characteristic of complex regional pain syndrome (CRPS). IL-6 is known to promote B cell differentiation, thus we hypothesized that IL-6 signaling plays a crucial role in the development of adaptive immune responses and nociceptive sensitization in a murine tibia fracture model of CRPS.