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Papers of the Week

Papers: 20 Feb 2021 - 26 Feb 2021


Human Studies

2021 Feb 20

Osteoarthritis Cartilage

The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain.


Akin-Akinyosoye K, James RJE, McWilliams DF, Millar B, das Nair R, Ferguson E, Walsh DA
Osteoarthritis Cartilage. 2021 Feb 20.
PMID: 33621705.


Pain is the prevailing symptom of knee osteoarthritis. Central sensitisation creates discordance between pain and joint pathology. We previously reported a central pain mechanisms trait derived from 8 discrete characteristics: neuropathic-like pain, fatigue, cognitive-impact, catastrophising, anxiety, sleep disturbance, depression, and pain distribution. We here validate and show that an 8-item questionnaire, Central Aspects of Pain in the Knee (CAP-Knee) is associated both with sensory and affective components of knee pain severity.