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Papers of the Week

Papers: 20 Feb 2021 - 26 Feb 2021

Animal Studies


2021 Feb 17

J Allergy Clin Immunol

Pituitary adenylate cyclase-activating polypeptide promotes cutaneous dendritic cell functions in contact hypersensitivity.


Yamamoto Y, Otsuka A, Ishida Y, San Wong L, Seidel JA, Nonomura Y, Nakashima C, Nakajima S, Kitoh A, Nomura T, Dainichi T, Honda T, Amano W, Konishi N, Hayashi M, Matsushita M, Kabashima K
J Allergy Clin Immunol. 2021 Feb 17.
PMID: 33609627.


Sensory nerves regulate cutaneous local inflammation indirectly through induction of pruritus and directly by acting upon local immune cells. The underlying mechanisms for how sensory nerves influence cutaneous acquired immune responses remain to be clarified.