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Papers of the Week


2021 Feb 18


J Ethnopharmacol

Inhibitory mechanism of O-methylated quercetins, highly potent β-secretase inhibitors isolated from Caragana balchaschensis (Kom.) Pojark.

Authors

Zhumanova K, Lee G, Baiseitova A, Shah A B, Kim J H, Kim J Y, Lee K W, Park K H
J Ethnopharmacol. 2021 Feb 18:113935.
PMID: 33609726.

Abstract

Caragana has a standing history of implementation in Traditional Chinese Medicine (TCM). Most species of this genus have been explored for multi-functional purposes, such as promoting blood circulation and curing neuralgia, fatigue, migraine, arthritis, and vascular hypertension (Meng et al., 2009). Among them, the well-known species C. sinica showed the most promising potential to increase the expression of ADAM10 among 313 tested medicinal plants, which is one of the promising approach for the treatment of Alzheimer's disease (AD). (Schuck et al., 2015).