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Papers of the Week

Papers: 20 Feb 2021 - 26 Feb 2021

Animal Studies

2021 Feb 17

Mol Brain



The IL33 receptor ST2 contributes to mechanical hypersensitivity in mice with neuropathic pain.


Huang J, Gadotti VM, Zhang Z, Zamponi GW
Mol Brain. 2021 Feb 17; 14(1):35.
PMID: 33596932.


Pathogen infection triggers pain via activation of the innate immune system. Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are the main components of innate immunity and have been implicated in pain signaling. We previously revealed that the TLR2-NLRP3-IL33 pathway mediates inflammatory pain responses during hyperactivity of innate immunity. However, their roles in neuropathic pain had remained unclear. Here we report that although knockout of TLR2 or NLRP3 does not affect spared nerve injury (SNI)-induced neuropathic pain, intrathecal inhibition of IL33/ST2 signaling with ST2 neutralizing antibodies reverses mechanical thresholds in SNI mice compared to PBS vehicle treated animals. This effect indicates a universal role of IL33 in both inflammatory and neuropathic pain states, and that targeting the IL33/ST2 axis could be a potential therapeutic approach for pain treatment.