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Papers of the Week

2021 Feb 15

J Invest Dermatol

Infusion of pituitary adenylate cyclase-activating polypeptide-38 in patients with rosacea induces flushing and facial edema which can be attenuated by sumatriptan.


Wienholtz N K F, Christensen C E, Coskun H, Zhang D G, Ghanizada H, Egeberg A, Thyssen JP, Ashina M
J Invest Dermatol. 2021 Feb 15.
PMID: 33600826.


The pathogenesis of rosacea is incompletely understood. Signaling neuropeptides including pituitary adenylate cyclase-activating polypeptide (PACAP), a regulator of vasodilation and edema, are upregulated in rosacea skin. Here, we evaluated PACAP38-induced rosacea features and examined whether a 5-HT receptor agonist could reduce these features.