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Papers of the Week
Infusion of pituitary adenylate cyclase-activating polypeptide-38 in patients with rosacea induces flushing and facial edema which can be attenuated by sumatriptan.
Abstract
The pathogenesis of rosacea is incompletely understood. Signaling neuropeptides including pituitary adenylate cyclase-activating polypeptide (PACAP), a regulator of vasodilation and edema, are upregulated in rosacea skin. Here, we evaluated PACAP38-induced rosacea features and examined whether a 5-HT receptor agonist could reduce these features.