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Papers of the Week

2021 Feb 15

J Gynecol Obstet Hum Reprod

Intrahepatic cholestasis of pregnancy associated with azathioprine: a case series.


Céruti H, Kayem G, Guilbaud L, Dussaux C, Gervais A, Beaufrère A, Coffin B, Mandelbrot L, Maisonneuve E
J Gynecol Obstet Hum Reprod. 2021 Feb 15:102083.
PMID: 33601075.


Intrahepatic cholestasis of pregnancy (ICP) is characterised by otherwise unexplained maternal pruritus, increased serum bile acid concentration over 10 µmol/L and spontaneous relief of symptoms and liver abnormalities after delivery. It occurs most frequently during the third trimester and is usually not induced by medication. Besides, azathioprine is recommended as first-line immunosuppressant in patients with steroid-dependent inflammatory bowel disease and is allowed during pregnancy, in order to stabilize maternal disease.