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Papers of the Week

2021 Mar



Detect it so you can treat it: A case series and proposed checklist to detect neurotoxicity in checkpoint therapy.


Bolz S, Ramakrishnan T, Fleischer M, Livingstone E, Stolte B, Thimm A, Kizina K, Ugurel S, Kleinschnitz C, Glas M, Zimmer L, Hagenacker T
eNeurologicalSci. 2021 Mar; 22:100324.
PMID: 33604462.


Checkpoint inhibitors show impressive and durable responses in various cancer types and provide new avenues for cancer immunotherapy. However, these drugs have a variety of adverse events. Common autoimmune-related adverse effects include fatigue, hepatitis, skin rash, endocrine deficiencies, and colitis. Neurotoxicity has been reported, but its incidence and course remain unclear.