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Papers of the Week

Papers: 6 Feb 2021 - 12 Feb 2021

Human Studies


Front Neurosci


The Effect of Spinal Cord Stimulation Frequency on the Neural Response and Perceived Sensation in Patients With Chronic Pain.


Gmel G E, Santos Escapa R, Parker JL, Mugan D, Al-Kaisy A, Palmisani S
Front Neurosci. 2021; 15:625835.
PMID: 33551738.


The effect of spinal cord stimulation (SCS) amplitude on the activation of dorsal column fibres has been widely studied through the recording of Evoked Compound Action Potentials (ECAPs), the sum of all action potentials elicited by an electrical stimulus applied to the fibres. ECAP amplitude grows linearly with stimulus current after a threshold, and a larger ECAP results in a stronger stimulus sensation for patients. This study investigates the effect of stimulus frequency on both the ECAP amplitude as well as the perceived stimulus sensation in patients undergoing SCS therapy for chronic back and/or leg pain.