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Papers: 30 Jan 2021 - 5 Feb 2021

2021 Feb 03

Eur J Pain

Is opioid therapy for chronic noncancer pain associated with a greater risk of all-cause mortality compared to non-opioid analgesics? A systematic review of propensity score matched observational studies.


The many risks associated with opioid therapy for chronic noncancer pain (CNCP) have led to questions about use. This is particularly relevant for risk of increased mortality. However, underlying medical conditions of those using opioids may influence mortality findings due to confounding by indication. Similarly, non-opioid analgesics are also associated with an increased risk of mortality, too.