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Papers of the Week

Papers: 30 Jan 2021 - 5 Feb 2021

Animal Studies

2021 Feb 01

Exp Physiol

Comparison of murine behavioral and physiologic responses after forced exercise by electrical shock vs. manual prodding.


Khataei T, Romig-Martin SA, Harding A MS, Radley JJ, Benson CJ
Exp Physiol. 2021 Feb 01.
PMID: 33527606.


What is the central question of this study? Forced treadmill exercise using electrical shock is the most common technique in rodent exercise studies. Here we examined how using electrical shock during forced treadmill exercise effects behavioral and physiological responses compared to a novel non-electrical shock technique. What is the main finding and its importance? Mice that underwent forced running using a novel technique involving gentle prodding to induce running showed 1) higher locomotor activity, 2) less anxiety-like behavior, and 3) altered exercise-induced muscle pain immediately after exercise compared to mice that underwent traditional treadmill running induced by electrical shock.