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Evid Based Complement Alternat Med


Comparison of Effects and Brain-Gut Regulatory Mechanisms of Acupuncture and Flunarizine for Migraine: Study Protocol for a Randomized Controlled Trial.


Wang Y-N, Sun M-S, Ni X-X, Tian T, Liu L, Li X, Xu T, Zhou S-Y, Chen J, Liang F-R, Liu J-X, Zhao L
Evid Based Complement Alternat Med. 2021; 2021:5676718.
PMID: 33505495.


As a central nervous system disease, migraine often coexists with gastrointestinal disorders, which suggests a disruption of brain-gut regulation. Clinical studies have confirmed that acupuncture and flunarizine not only alleviate migraine attacks but also substantially inhibit accompanying gastrointestinal symptoms. However, it is still not clear how acupuncture and flunarizine regulate the interactions of brain, gut, and microbiome. Therefore, this study will combine neuroimaging technology and gut microbiota detection technology to explore and compare the effects and brain-gut modulating mechanisms of acupuncture and flunarizine for migraine.