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Papers of the Week

2021 Jan 28

Inflamm Res

Regulation of Toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus.


Tao B, Xiang W, Li X, He C, Chen L, Xia X, Peng T, Peng L, Yang X, Zhong C
Inflamm Res. 2021 Jan 28.
PMID: 33507312.


microRNAs (miRNAs) play critical roles in embryogenesis, cell differentiation and the pathogenesis of several human diseases, including systemic lupus erythematosus (SLE). Toll-like receptors (TLRs) are also known to exert crucial functions in the immune response activation occurring in the pathogenesis of autoimmune diseases like SLE. Herein, the current study aimed to explore the potential role of miR-152-3p in TLR-mediated inflammatory response in SLE.