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Papers of the Week


Papers: 23 Jan 2021 - 29 Jan 2021


Animal Studies


2021 Jan 27


Pediatr Res

Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model.

Authors

van den Hoogen NJ, de Geus TJ, Patijn J, Tibboel D, Joosten EA
Pediatr Res. 2021 Jan 27.
PMID: 33504957.

Abstract

Painful procedures in early life cause acute pain and can alter pain processing at a spinal level lasting into adulthood. Current methods of analgesia seem unable to prevent both acute and long-term hypersensitivity associated with neonatal pain. The current study aims to prevent acute and long-term hypersensitivity associated with neonatal procedural pain using methadone analgesia in rat pups.