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Papers of the Week

Papers: 23 Jan 2021 - 29 Jan 2021

Human Studies

2021 Jan 25




Efficacy of different spinal cord stimulation paradigms for the treatment of chronic neuropathic pain (PARS-trial): study protocol for a double-blinded, randomized, and placebo-controlled crossover trial.


Ahmadi R, Campos B, Hajiabadi M M, Doerr-Harim C, Tenckhoff S, Rasche D, Unterberg A, Vesper J, Bruckner T, Tronnier V
Trials. 2021 Jan 25; 22(1):87.
PMID: 33494781.


Spinal cord stimulation (SCS) is an effective method to treat neuropathic pain; however, it is challenging to compare different stimulation modalities in an individual patient, and thus, it is largely unknown which of the many available SCS modalities is most effective. Specifically, electrodes leading out through the skin would have to be consecutively connected to different, incompatible SCS devices and be tested over a time period of several weeks or even months. The risk of wound infections for such a study would be unacceptably high and blinding of the trial difficult. The PARS-trial seizes the capacity of a new type of wireless SCS device, which enables a blinded and systematic intra-patient comparison of different SCS modalities over extended time periods and without increasing wound infection rates.