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Papers of the Week
Allergens TRP a swITCH to Initiate Type 2 Immunity.
Authors
PMID: 33207213.
Abstract
Allergens induce type-2 immunity, but unresolved questions remain about initiation of this response. In this issue, Perner et al. propose that cutaneous activation of TRPV1 sensory neurons by protease allergens stimulates release of substance P to induce migration of Th2-skewing CD301b DC to draining lymph nodes.