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Papers of the Week


Papers: 23 Jan 2021 - 29 Jan 2021


Human Studies


2021 Jan 23


Diabetologia

Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy.

Authors

Karlsson P, Gylfadottir SS, Kristensen AG, Ramirez JD, Cruz P, Le N, Shillo PR, Tesfaye S, Rice ASC, Tankisi H, Finnerup NB, Nyengaard JR, Jensen TS, Bennett DLH, Themistocleous AC
Diabetologia. 2021 Jan 23.
PMID: 33483760.

Abstract

Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quantification altered in DSP. It is, however, unclear if axonal swellings are related to diabetes or DSP. The aim of this study was to investigate how axonal swellings in cutaneous nerve fibres are related to type 2 diabetes mellitus, DSP and neuropathic pain in a well-defined cohort of patients diagnosed with type 2 diabetes.