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Papers of the Week

2021 Jan 18

Int J Environ Res Public Health



Subjective Psychophysical Experiences in the Course of Inflammatory Bowel Disease-A Comparative Analysis Based on the Polish Pediatric Crohn’s and Colitis Cohort (POCOCO).


Glapa-Nowak A, Bukowska-Posadzy A, Szczepanik M, Kwiecień J, Szaflarska-Popławska A, Iwańczak B, Flak-Wancerz A, Dembiński Ł, Osiecki M, Kierkuś J, Banasiewicz T, Walach H, Banaszkiewicz A, Walkowiak J
Int J Environ Res Public Health. 2021 Jan 18; 18(2).
PMID: 33477658.


No gold standard is available to evaluate subjective psychophysical experiences in pediatric inflammatory bowel disease (IBD). We aimed to assess pain, anxiety, and limitations in social activities at diagnosis and the worst flare of the disease in relation to clinical expression, treatment and IBD severity. A total of 376 children completed the survey (Crohn's disease (CD) n = 196; ulcerative colitis (UC) n = 180). The questionnaire included 12 questions regarding pain, anxiety, and social activity, all assessed at recruitment and retrospectively at diagnosis and worst flare using a numeric rating scale. Patients that had ever been treated with systemic glucocorticosteroids scored higher in pain ( < 0.001), anxiety ( = 0.015), and social activity domains ( < 0.016) at worst flare, and the answers correlated with the number of steroid courses ( < 0.0392). The perception of social activity limitations also correlated independently with the number of immunosuppressants ( < 0.0433) and biological agents ( < 0.0494). There was no difference in retrospective perception of pain, anxiety and social activity limitations between CD and UC patients at diagnosis and the worst flare. The level of limitations in social activity correlated with hospitalisations due to relapse, days spent in the hospital, number of relapses, and severe relapses with the strongest association of rho = 0.39 ( = 0.0004). Subjective and retrospective perception of pain, anxiety, and limitations in social activity differs depending on therapy, correlates with treatment modalities, and severity measures such as hospitalisations.