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Papers of the Week
P2X7-induced nociception in the temporomandibular joint of rats depends on inflammatory mechanisms and C-fibers sensitization.
Abstract
P2X7 receptors are responsible for triggering inflammatory responses contributing to processes of pain in articular tissues. This study aimed to investigate whether the activation of the P2X7 receptor located in the temporomandibular joint (TMJ) tissues induces nociception through an inflammatory mechanisms and/or the activation of C-fibers (small-diameter primary afferents) of rats' TMJ.