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Papers of the Week

Papers: 16 Jan 2021 - 22 Jan 2021

Human Studies

2020 Nov 20

BMJ Open



Protocol for an economic analysis of the randomised controlled trial of Improving the Well-being of people with Opioid Treated CHronic pain: I-WOTCH Study.


Manchira Krishnan S, Gc V S, Sandhu H K, Underwood M, Eldabe S, Manca A, Iglesias Urrutia CP
BMJ Open. 2020 Nov 20; 10(11):e037243.
PMID: 33444175.


Over the last two decades, the use of opioids for the treatment of chronic pain in England has steadily increased despite lack of evidence of both long-term effectiveness in pain relief and significant, well-documented physical and mental adverse events. Guidelines recommend tapering when harms outweigh benefits, but the addictive nature of opioids hinders simple dose-reduction strategies. Improving the Well-being of people with Opioid Treated CHronic pain (I-WOTCH) trial tests a multicomponent self-management intervention aimed to help patients with chronic non-malignant pain taper opioid doses. This paper outlines the methods to be used for the economic analysis of the I-WOTCH intervention compared with the best usual care.