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Papers of the Week

2021 Jan 12

Life (Basel)



Effect of Gabapentin in a Neuropathic Pain Model in Mice Overexpressing Human Wild-Type or Human Mutated Torsin A.


Scuteri D, Rombolà L, Natoli S, Pisani A, Bonsi P, Watanabe C, Bagetta G, Tonin P, Corasaniti M T
Life (Basel). 2021 Jan 12; 11(1).
PMID: 33445430.


DYT1 dystonia is the most common form of early-onset inherited dystonia, which is caused by mutation of torsin A (TA) belonging to the "ATPases associated with a variety of cellular activities" (AAA + ATPase). Dystonia is often accompanied by pain, and neuropathic pain can be associated to peripherally induced movement disorder and dystonia. However, no evidence exists on the effect of gabapentin in mice subjected to neuropathic pain model overexpressing human normal or mutated TA.