I am a
Home I AM A Search Login

Papers of the Week

Papers: 16 Jan 2021 - 22 Jan 2021

Human Studies, Pharmacology/Drug Development

2021 Jan 12

J Clin Med



Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study.


Yoon H J, Kim J, Yang J M, Wei ET, Kim S J, Yoon K C
J Clin Med. 2021 Jan 12; 10(2).
PMID: 33445485.


Activation of TRPM8, a cold-sensing receptor located on the cornea and eyelid, has the potential to relieve the neuropathic ocular pain (NOP) in dry eye (DE) by inhibiting other aberrant nociceptive inputs. We aimed to investigate the effect of a topical TRPM8 agonist, cryosim-3 (C3), on relieving DE-associated NOP.