Background Atopic dermatitis is a chronic inflammatory skin disease characterized by pruritic, dry, and eczematous lesions. The effect of atopic dermatitis on the quality of patients' lives has been investigated. However, its impact on the quality of sleep is still controversial. Objective This study aims to identify the correlation between sleep quality and atopic dermatitis disease among adults living in Saudi Arabia. Design and setting This is a cross-sectional, quantitative survey study, carried out during July and August 2020, which included atopic dermatitis patients. The study used Arabic versions of a self-administered, Internet-based questionnaire of the Pittsburgh Sleep Quality Index (PSQI) and Dermatology Life Quality Index (DLQI). Face-to-face patient interviews were not applicable due to the COVID-19 pandemic. Results A total of 400 patients participated in this survey study. Eighty-six percent (86%) were females while 39.6% were in the age group of 18 to 25 years old. A third of the responders could not sleep within half an hour, and a third of them woke up at night or early in the morning more than three times a week. Twenty-three point eight percent (23.8%) of the responders rated their sleep quality as a very good quality of sleep while 17.8% rated it as very bad. Inability to get to sleep within half an hour (p-value=0.002), waking up at night (p-value=0.005), and not being able to sleep because of pain (p-value<0.001) were all significantly correlated to the occurrence of many or a lot of skin symptoms of atopic dermatitis. There was a significantly higher total score among patients with atopic dermatitis (p value<0.001), which shows a poorer quality of sleep. Conclusion Symptoms of atopic dermatitis negatively influence the quality of sleep of adults in Saudi Arabia. The frequency of symptoms are significantly correlated to the poor quality of sleep. Therefore, we suggest that the evaluation of sleep quality is necessary for the management of atopic dermatitis patients.