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Papers of the Week

2019 Aug

Int J Cardiol Hypertens


Diagnosis and treatment of neuroendocrine tumors – A series of 13 clinical cases (2014-2017).


Sepúlveda Santos T, Figueira A, Rocha J, Coutinho J, Carvalho L, Ducla-Soares JL
Int J Cardiol Hypertens. 2019 Aug; 2:100019.
PMID: 33447750.


Paragangliomas and pheocromocytomas are rare neuroendocrine tumors with different clinical presentation, being responsible for secondary arterial hypertension with target-organ lesions. Surgery is a curative therapy in these tumors and demands a multidisciplinary approach. These tumors are more frequent between the 4th and 5th decades of life and their clinical manifestations are related to catecholamines production: headache, palpitations, variable blood pressure. This article presents 13 clinical cases of patients with neuroendocrine tumors, with an median-age of 56,7 years, submitted to surgery between 2014 and 2017. The diagnosis was made based on clinical suspicion, serum and urinary catecholamines and metanephrins, imagiologic evaluation with CT or abdominal and pelvic MRI and MIBG scintigraphy. After surgery, the majority of patients remained with normal blood pressure, without anti-hypertensive therapy and follow-up was maintained in Outpatient Clinic, with periodic blood tests and imaging reevaluation.