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Papers of the Week

Papers: 9 Jan 2021 - 15 Jan 2021

Animal Studies, Pharmacology/Drug Development

2021 Jan 09

Brain Behav Immun

Targeting Peroxisome Proliferator-Activated Receptor-α (PPAR- α) to Reduce Paclitaxel-Induced Peripheral Neuropathy.


Caillaud M, Patel NH, White A, Wood M, Contreras KM, Toma W, Alkhlaif Y, Roberts JL, Tran TH, Jackson AB, Poklis J, Gewirtz DA, Imad Damaj M
Brain Behav Immun. 2021 Jan 09.
PMID: 33434562.


Paclitaxel, a widely used anti-cancer drug, is frequently associated with prolonged and severe peripheral neuropathies (PIPN), associated with neuroinflammation. Currently, PIPN effective treatments are lacking. Peroxisome Proliferator-Activated Receptor-α (PPAR-⍺) can modulate inflammatory responses. Thus, the use of PPAR-⍺ agonists, such as fibrates (fenofibrate and choline-fenofibrate), currently used in dyslipidemia treatment, could represent an interesting therapeutic approach in PIPN.