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Papers of the Week

2021 Jan 05

Life Sci

TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves.


Liu J, Zhao M, Chen Z, Xu Y, Guo L, Wang S, Li Y, Shi B, Zhang X, Jin X-D
Life Sci. 2021 Jan 05:118967.
PMID: 33417951.


Sensory nerve activation modulates ureteral contractility by releasing neuropeptides including CGRP and neurokinin A (NKA). TRPM3 is a recently discovered thermosensitive channel expressed in nociceptive sensory neurons, and plays a key role in heat nociception and chronic pain. The aim of this study is to examine the role of TRPM3 activation in human ureter motility.