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Papers of the Week

2020 Dec 28

Arch Soc Esp Oftalmol

Painful ophthalmoplegia syndrome, beyond Tolosa-Hunt syndrome. A case series.


Arenas Díaz RD, de Calderón Castro AP
Arch Soc Esp Oftalmol. 2020 Dec 28.
PMID: 33384172.


Painful ophthalmoplejía syndrome is characterised by the presence of peri-orbital or peri-cranial pain that is accompanied by paralysis of the oculomotor nerves. The differential diagnosis is broad, and requires a rigorous study. Three clinical cases of patients with painful ophthalmoplejía syndrome are described, in which multiple extension studies were required to obtain an aetiological diagnosis. Painful ophthalmoplejía syndrome is a complex disorder that has multiple causes, including infections, inflammatory, and tumour processes. Biopsy should be considered in those cases in which non-invasive studies are inconclusive.