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Papers of the Week

Papers: 8 Aug 2020 - 14 Aug 2020

Human Studies, Pharmacology/Drug Development

2020 Jul 01




Editor's Pick

Ketamine and Magnesium for Refractory Neuropathic Pain.


Pickering G, Pereira B, Morel V, Corriger A, Giron F, Marcaillou F, Bidar-Beauvallot A, Chandeze E, Lambert C, Bernard L, Delage N
Anesthesiology. 2020 Jul 01; 133(1):154-164.
PMID: 33377922.


Ketamine is often used for the management of refractory chronic pain. There is, however, a paucity of trials exploring its analgesic effect several weeks after intravenous administration or in association with magnesium. The authors hypothesized that ketamine in neuropathic pain may provide pain relief and cognitive-emotional benefit versus placebo and that a combination with magnesium may have an additive effect for 5 weeks.