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Papers of the Week
Neurokinin-1 receptor antagonist tradipitant has mixed effects on itch in atopic dermatitis: Results from EPIONE, a randomized clinical trial.
Abstract
Atopic dermatitis (AD) is a relapsing and remitting disease characterized by intense pruritus that can lead to scratching and eczematous lesions that vary in extent and severity . Over 60% of AD cases are mild, characterized by slight erythema, induration, and lichenification . Chronic pruritus, pruritus lasting more than 6 weeks, has been reported by 91% of AD patients . The pathophysiology of AD is driven by a combination of skin barrier dysfunction, neuroinflammation, and immune system dysregulation .