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Papers of the Week


Papers: 12 Dec 2020 - 18 Dec 2020


Animal Studies, Pharmacology/Drug Development


2021 Jan 01


Anesthesiology


134


1

Editor's Pick

L-bupivacaine Inhibition of Nociceptive Transmission in Rat Peripheral and Dorsal Horn Neurons.

Authors

Uta D, Koga K, Furue H, Imoto K, Yoshimura M
Anesthesiology. 2021 Jan 01; 134(1):88-102.
PMID: 33166389.

Abstract

Although the widely used single L-enantiomers of local anesthetics have less toxic effects on the cardiovascular and central nervous systems, the mechanisms mediating their antinociceptive actions are not well understood. The authors hypothesized that significant differences in the ion channel blocking abilities of the enantiomers of bupivacaine would be identified.