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Papers of the Week

Papers: 12 Dec 2020 - 18 Dec 2020

Animal Studies

2020 Dec 07

Br J Anaesth

Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through downregulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones.


Zhang Z, Zheng B, Du S, Han G, Zhao H, Wu S, Jia S, Bachmann T, Bekker A, Tao Y-X
Br J Anaesth. 2020 Dec 07.
PMID: 33303185.


Nerve injury-induced changes in gene expression in the dorsal root ganglion (DRG) contribute to neuropathic pain genesis. Eukaryotic initiation factor 4 gamma 2 (eIF4G2) is a general repressor of cap-dependent mRNA translation. Whether DRG eIF4G2 participates in nerve injury-induced alternations in gene expression and nociceptive hypersensitivity is unknown.