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Papers of the Week

2020 Dec 01

Rev Recent Clin Trials

Intravenous Magnesium – Lidocaine – Ketorolac Cocktail for Postoperative Opioid Resistant Pain: A Case Series of Novel Rescue Therapy.


Zanza C, Longhitano Y, Lin E, Luo J, Artico M, Savarese B, Bonato V, Piccioni A, Franceschi F, Taurone S, Abenavoli L, Berger J M
Rev Recent Clin Trials. 2020 Dec 01.
PMID: 33267764.


Severe postoperative pain is principally managed by opioids. While effective, opioids do not provide adequate relief in many patients and cause many side effects including antinociceptive tolerance and opioid-induced hyperalgesia. To evaluate if a combination of intravenous Magnesium, Lidocaine, Ketorolac (MLK cocktail) is a useful rescue therapy through synergistic pharmacological mechanisms for acute pain relief. We present the intravenous combination of magnesium, lidocaine, and ketorolac (MLK cocktail) as a possible rescue for opioid insensitive severe postoperative pain.