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Papers of the Week


2020 Dec 01


medRxiv

Identification of optimal symptom combinations to trigger diagnostic work-up of suspected COVID-19 cases: analysis from a community-based, prospective, observational cohort.

Authors

Antonelli M, Capdevila J, Chaudhari A, Granerod J, Canas L, Graham M, Klaser K, Modat M, Moldeni E, Murray B, Sudre C, Davies R, May A, Nguyen L, Drew D, Joshi A, Chan A, Cramer J, Spector T, Wolf J, et al.
medRxiv. 2020 Dec 01.
PMID: 33269364.

Abstract

Several COVID-19 vaccine efficacy trials are ongoing with others predicted to start soon. Diagnostic work-up of trial participants following any COVID-19 associated symptom will lead to extensive testing, potentially overwhelming laboratory capacity whilst primarily yielding negative results. We aimed to identify an efficient symptom combination to capture most cases using the lowest possible number of tests.