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Antinociceptive Effect of Vapocoolant Medium Stream Spray onHotplate LatencyinRat Pups.
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Abstract
Heel sticks account formostblood tests performed in neonateswithout analgesia because topical localanestheticsare ineffective on heelglabrous skin. We investigated the antinociceptive effect of an alternative topical analgesic, avapocoolant spray, on hindpaws glabrous skin of rat pups. The spray was applied by two methods: method-1 for 4 seconds at a distance of 8 cm and method-2 for 10 seconds at a distance of 18 cm.