I am a
Home I AM A Search Login

Papers of the Week


Papers: 28 Nov 2020 - 4 Dec 2020


Animal Studies, Pharmacology/Drug Development


2020 Nov 24


Anesth Analg

Nonopioid GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses.

Authors

Zhou Y, Leung-Pitt Y, Deng H, Ren Y, You Z, Kem WR, Shen S, Zhang W, Mao J, Martyn JJA
Anesth Analg. 2020 Nov 24.
PMID: 33264122.

Abstract

Burn injury (BI) pain consists of inflammatory and neuropathic components and activates microglia. Nicotinic alpha 7 acetylcholine receptors (α7AChRs) expressed in microglia exhibit immunomodulatory activity during agonist stimulation. Efficacy of selective α7AChR agonist GTS-21 to mitigate BI pain and spinal pain-mediators was tested.