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Papers: 28 Nov 2020 - 4 Dec 2020
Animal Studies, Pharmacology/Drug Development
2020 Nov 24
Anesth Analg
Burn injury (BI) pain consists of inflammatory and neuropathic components and activates microglia. Nicotinic alpha 7 acetylcholine receptors (α7AChRs) expressed in microglia exhibit immunomodulatory activity during agonist stimulation. Efficacy of selective α7AChR agonist GTS-21 to mitigate BI pain and spinal pain-mediators was tested.