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Papers of the Week

Papers: 28 Nov 2020 - 4 Dec 2020

Human Studies

2020 Nov 23

Drug Alcohol Depend

Non-invasive brain stimulation as a tool to decrease chronic pain in current opiate users: A parametric evaluation of two promising cortical targets.


Imperatore JP, McCalley DM, Borckardt JJ, Brady KT, Hanlon CA
Drug Alcohol Depend. 2020 Nov 23:108409.
PMID: 33250384.


Poorly controlled chronic pain can lead to non-prescription use of opiates, which is a growing crisis in our communities. Transcranial magnetic stimulation (TMS) is a non-invasive therapeutic tool which has emerged as a potential treatment option for these patients. It is still unclear, however, if the dorsolateral prefrontal cortex (DLPFC) or the motor cortex (MC) is a more effective treatment location. The purpose of this study was to directly compare the effects of DLPFC versus MC TMS on pain severity and the urge to use opiates among chronic pain patients.