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Papers of the Week

Papers: 28 Nov 2020 - 4 Dec 2020

Animal Studies, Pharmacology/Drug Development

2020 Nov 28

Br J Pharmacol

Activation of Trace Amine-Associated Receptor 1 Selectively Attenuates the Reinforcing Effects of Morphine.


Liu J, Seaman R, Johnson B, Wu R, Vu J, Tian J, Zhang Y, Li J-X
Br J Pharmacol. 2020 Nov 28.
PMID: 33247948.


Trace amine-associated receptor 1 (TAAR1) plays a critical role in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TAAR1 modulates addiction-like behaviors associated with psychostimulants. However, little is known about whether TAAR1 modulation would regulate the behavioral effects of opioids.