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Papers of the Week

Papers: 28 Nov 2020 - 4 Dec 2020

Human Studies

2020 Nov

RMD Open



Chronic back pain in first-degree relatives (FDRs) of patients with ankylosing spondylitis: predictive value of HLA-B27 and persistence of inflammatory back pain over time.


Doughem K, Weisman MH, Ward MM, Gensler LS, Ishimori M, Tahanan A, Kung DC, Diekman L, Lee MJ, Rahbar M H, Reveille JD
RMD Open. 2020 Nov; 6(3).
PMID: 33243782.


First-degree relatives (FDRs) of patients with ankylosing spondylitis (AS) may be at high risk of spondyloarthritis. We examined the frequency, characteristics of chronic back pain (CBP), associated features, persistence of symptoms, and HLA-B27 allele frequency in FDRs of AS patients, also comparing those FDRs with participants in NHANES 2009-2010 with CBP.