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Papers of the Week

Papers: 21 Nov 2020 - 27 Nov 2020

Human Studies

2020 Nov 25


Mechanisms for the Clinical Utility of Low-Frequency Stimulation in Neuromodulation of the Dorsal Root Ganglion.


Chapman KB, Yousef TA, Foster A, Stanton-Hicks MD, van Helmond N
Neuromodulation. 2020 Nov 25.
PMID: 33236811.


Dorsal root ganglion stimulation (DRG-S) involves the electrical modulation of the somata of afferent neural fibers to treat chronic pain. DRG-S has demonstrated clinical efficacy at frequencies lower than typically used with spinal cord stimulation (SCS). In a clinical study, we found that the frequency of DRG-S can be tapered to a frequency as low as 4 Hz with no loss of efficacy. This review discusses possible mechanisms of action underlying effective pain relief with very low-frequency DRG-S.