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Papers of the Week

2020 Nov 17

Int J Mol Sci



The Anti-Inflammatory Role of Bilirubin on “Two-Hit” Sepsis Animal Model.


Tran D T, Jeong Y Y, Kim J M, Bae H B, Son S K, Kwak S H
Int J Mol Sci. 2020 Nov 17; 21(22).
PMID: 33212789.


Bilirubin is a product of the heme catabolism pathway, and it is excreted in bile and removed from the body through the urine. Bilirubin has potent antioxidant properties but also plays a role in anti-inflammation by protecting the body against endotoxin-induced lung inflammation, down-regulating the expression of adhesion molecules, and inhibiting the infiltration of inflammatory cells. Thus, bilirubin is a promising agent that could use in inflammation disease treatment. The application of bilirubin on the "two-hit" sepsis animal model has been, to date, unknown.