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Papers of the Week

Papers: 7 Nov 2020 - 13 Nov 2020

Animal Studies


2020 Nov 08


Transient loss of interhemispheric functional connectivity following unilateral cortical spreading depression in awake rats.


Vinogradova LV, Suleymanova EM, Medvedeva TM
Cephalalgia. 2020 Nov 08:333102420970172.
PMID: 33164563.


Growing evidence shows a critical role of network disturbances in the pathogenesis of migraine. Unilateral pattern of neurological symptoms of aura suggests disruption of interhemispheric interactions during the early phase of a migraine attack. Using local field potentials data from the visual and motor cortices, this study explored effects of unilateral cortical spreading depression, the likely pathophysiological mechanism of migraine aura, on interhemispheric functional connectivity in freely behaving rats.