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Papers of the Week


Papers: 7 Nov 2020 - 13 Nov 2020


Animal Studies, Human Studies


2020 Nov 06


Mol Metab

Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.

Authors

Strom A, Strassburger K, Schmuck M, Shevalye H, Davidson E, Zivehe F, Bönhof G, Reimer R, Belgardt B-F, Fleming T, Biermann B, Burkart V, Müssig K, Szendroedi J, Yorek MA, Fritsche E, Nawroth PP, Roden M, Ziegler D
Mol Metab. 2020 Nov 06:101114.
PMID: 33166742.

Abstract

The lack of effective treatments against diabetic sensorimotor polyneuropathy demands the search for new strategies to combat or prevent the condition. Since reduced magnesium and increased methylglyoxal levels have been implicated in the development of both type 2 diabetes and neuropathic pain, we aimed to assess the putative interplay of both molecules with diabetic sensorimotor polyneuropathy.