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Papers of the Week

Papers: 7 Nov 2020 - 13 Nov 2020

Animal Studies, Human Studies


2020 Nov 10

J Headache Pain



Estrogen receptors α, β and GPER in the CNS and trigeminal system – molecular and functional aspects.


Warfvinge K, Krause DN, Maddahi A, Edvinsson JCA, Edvinsson L, Haanes KA
J Headache Pain. 2020 Nov 10; 21(1):131.
PMID: 33167864.


Migraine occurs 2-3 times more often in females than in males and is in many females associated with the onset of menstruation. The steroid hormone, 17β-estradiol (estrogen, E2), exerts its effects by binding and activating several estrogen receptors (ERs). Calcitonin gene-related peptide (CGRP) has a strong position in migraine pathophysiology, and interaction with CGRP has resulted in several successful drugs for acute and prophylactic treatment of migraine, effective in all age groups and in both sexes.