Papers of the Week

Osteoarthritis (OA) is an extraordinarily prevalent and disabling disease [1]. Current management options for pain and functional limitation are constrained by modest efficacy or a range of unwanted side effects. Our society is being impacted through underemployment and the opioid epidemic and our health care systems are overstretched, as a consequence of the trajectory of increasing joint replacement requirements [2]. In this context, development of new treatments or identification of efficacy of existing therapies to address the huge unmet need of pain are strongly desired.