I am a
Home I AM A Search Login

Papers of the Week

Papers: 7 Nov 2020 - 13 Nov 2020

Human Studies

2020 Nov 10

Eur J Pain

Conditioned Pain Modulation affects the N2/P2 complex but not the N1 wave: a pilot study with Laser-Evoked Potentials.


Squintani G, Rasera A, Segatti A, Concon E, Bonetti B, Valeriani M, Tinazzi M
Eur J Pain. 2020 Nov 10.
PMID: 33170987.


The "pain-inhibits-pain"' effect stems from neurophysiological mechanisms involving endogenous modulatory systems termed diffuse noxious inhibitory controls (DNIC) or conditioned pain modulation (CPM). Laser-evoked potentials (LEPs) components, the N2/P2 complex, and the N1 wave, reflect the medial and lateral pain pathway, respectively: anatomically, the lateral thalamic nuclei (LT) project mainly to the somatosensory cortex (N1 generator), while the medial thalamic nuclei (MT) are bound to the limbic cortices (N2/P2 generators).