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Papers of the Week

Papers: 7 Nov 2020 - 13 Nov 2020


2020 Nov 07

Behav Brain Res

Emotional and cognitive impairments in the peripheral nerve chronic constriction injury model (CCI) of neuropathic pain: a systematic review.


Fonseca-Rodrigues D, Amorim D, Almeida A, Pinto-Ribeiro F
Behav Brain Res. 2020 Nov 07:113008.
PMID: 33171146.


Emotional and cognitive impairments are common comorbidities of chronic neuropathic pain that significantly impact the quality of life of patients. While the nociceptive components of the peripheral nerve chronic constriction injury (CCI) animal model have been extensively analyzed, data related to the development of mood and cognitive disorders, and especially its impact on female rats remains fragmented. We systematically reviewed the literature analyzing the methods used to induce and evaluate the development of emotional- and cognitive-like impairments and sex-specific differences in the CCI model.