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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice.

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2020 Nov 04


Adv Rheumatol


http://www.ncbi.nlm.nih.gov/pubmed/33148336?dopt=Abstract


60


1

Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice.

Authors

Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice.
Lin X, Shao T, Wen X, Wang M, Wen C, He Z
Adv Rheumatol. 2020 Nov 04; 60(1):52.
PMID: 33148336.

Abstract

Gout is characterized by inflammatory arthritis with hyperuricaemia and deposition of monosodium urate (MSU) crystals in the joints. Several animal models have been proposed based on MSU crystals injection or high-fat diet feeding; however, neither hyperuricaemia model nor acute gout model can effectively reflect clinical features of gout. This study aimed to assess the effectiveness of a compound gout model induced by the combination of MSU crystals injection and high-fat diet feeding.
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